Wei-Hao ChiuAcademic Profile

International Journal Publication

Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings

Author affiliations and roles
  1. a1 Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan; yijenhua@gmail.com (Y.-J.H.); judy91206@gmail.com (R.-Y.L.); skyforest1316@gmail.com (C.-H.Z.)
  2. b2 Center for Green Technology, Chang Gung University, Taoyuan 33302, Taiwan; weihao.chiu@gmail.com
  3. cChang Gung University of Science and Technology
  4. d3 Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan
  5. e4 Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan
  • *Corresponding authors: Huang, Yi-Jen, Huang, Chien-Lin, Lee, Kun-Mu.

Polymers, 13, 4246 (2021).

Research topic: Other Materials & Photonics

Abstract

In this study, polycaprolactone (PCL)- and poly(acrylic acid) (PAA)-based electrospun nanofibers were prepared for the carriers of antimicrobials and designed composite nanofiber mats for chronic wound care. The PCL- and PAA-based electrospun nanofibers were prepared through in situ polymerization starting from PCL and acrylic acid (AA). Different amounts of AA were introduced to improve the hydrophilicity of the PCL electrospun nanofibers. A compatibilizer and a photoinitiator were then added to the electrospinning solution to form a grafted structure composed of PCL and PAA (PCL-g-PAA). The grafted PAA was mainly located on the surface of a PCL nanofiber. The optimization of the composition of PCL, AA, compatibilizer, and photoinitiator was studied, and the PCL-g-PAA electrospun nanofibers were characterized through scanning electron microscopy and H-1-NMR spectroscopy. Results showed that the addition of AA to PCL improved the hydrophilicity of the electrospun PCL nanofibers, and a PCL/AA ratio of 80/20 presented the best composition and had smooth nanofiber morphology. Moreover, poly[2 -(tert-butylaminoethyl) methacrylate]-grafted graphene oxide nanosheets (GO-g-PTA) functioned as an antimicrobial agent and was used as filler for PCL-g-PAA nanofibers in the preparation of composite nanofiber mats, which exerted synergistic effects promoted by the antibacterial properties of GO-g-PTA and the hydrophilicity of PCL-g-PAA electrospun nanofibers. Thus, the composite nanofiber mats had antibacterial properties and absorbed body fluids in the wound healing process, thereby promoting cell proliferation. The biodegradation of the PCL-g-PAA electrospun nanofibers also demonstrated an encouraging result of three-fold weight reduction compared to the neat PCL nanofiber. Our findings may serve as guidelines for the fabrication of electrospun nanofiber composites that can be used mats for chronic wound care.

Graphical Abstract

Graphical abstract for Microstructure and Biological Properties of Electrospun In Situ Polymerization of Polycaprolactone-Graft-Polyacrylic Acid Nanofibers and Its Composite Nanofiber Dressings
Graphical abstract

Keywords

electrospinningin situ polymerizationpolycaprolactonepoly(acrylic acid)graftingnanofibergraphene oxidesphotoinitiatorhydrophilicwound healingethylene glycol dimethyl acrylatepoly[2-(tert-butylaminoethyl) methacrylate]
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